Take the Long Island Expressway (Route 495) to Exit 62. Proceed north on County Road 97 (Nicolls Road) to its end. Turn left onto Route 25A for 1-1 1/2 miles, to the intersection of 25A and Main Street in Stony Brook. Turn Left.
The Museums main entrance is on the right. Driving time from New York City approximately an hour to one and one half hours.